KeriMedical

Reaxon®

The only CHITOSAN based Nerve Regrowth and Protection Tube.

  • Flexible and transparent
  • Does not collapse
  • Easy to suture (hydrogel)
  • Consist of polysaccharides

WHAT IS CHITOSAN?

  • Chitosan is a cationic polysaccharide of natural origin obtained by alkaline deacetylation of chitin.
  • The chitin used in the production of Reaxon® tubes is of natural origin.

Chitosan tubes are:

  • Biodegradable – they degrade to compounds that can be metabolized by the body1
  • Bioactive – they stimulate the growth of nerve cells2
  • Biocompatible – they do not induce any immune response3
  • Antiadherent – they limit the formation of scar tissue4
  • Antifungal, Antibacterial5
  • Hemostatic1

ADVANTAGES OF CHITOSAN IN THE USE OF REAXON® TUBES

  • The transparency of the tubes enables effective positioning of the fascicles and early detection of blood clots.
  • Thanks to the mechanical properties of the tubes, suturing is facilitated (even with 9-0 sutures).
  • Very low risk of an immune response: non-protein origin; not of porcine or bovine origin.
  • Bioactive:
    • limits adherences4
    • promotes macrocyte growth6
    • positive effect on Schwann cell growth7
  • Good tube integrity for 18 months (resorption at 2.5 years)2
  • Nerve repair without tension to enhance healing and function recovery.

ADVANTAGES OF REAXON®

  • No morbidity or loss of feeling at the donor site.
  • Does not collapse.
  • Highly transparent enabling optimal positioning of the nerve endings and detection of blood clots.
  • Semi-permeable enabling small nutrients and neurotropic factors to cross the tube.
  • The metabolic degradation products are resorbed via normal metabolic pathways.
  • Good tube integrity for 18 months (resorption at 2.5 years).

Two versions are available:

/ REAXON® NERVE GUIDE
Assists nerve regrowth when a direct suture is not possible (for sutures with a loss of substance of up to 26 mm)

Catalog Number Inner Diameter Lenght
RG321 2.1 mm 30 mm
RG330 3.0 mm 30 mm
RG340 4.0 mm 30 mm
RG350 5.0 mm 30 mm
RG360 6.0 mm 30 mm

/ REAXON® DIRECT
Enables protection when there is little or no loss of matter

Catalog Number Inner Diameter Lenght
RD121 2.1 mm 14 mm
RD130 3.0 mm 14 mm
RD140 4.0 mm 14 mm
RD150 5.0 mm 14 mm
RD160 6.0 mm 14 mm

Product presentation

Publications and research


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Clinical Trials Medovent


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Enhancing the Outcome of Traumatic Sensory Nreve Lesions of the Hand by Additional Use of a Chitosan Nerve Tube in Primary Nerve Repair: A Randomized Controlled Bicentric Trial


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Chitosan tubes of varying degrees of acetylation for bridging peripheral nerve defects

References:

  1. Croisier F, Jérôme C. Chitosan-based biomaterials for tissue engineering. European Polymer Journal. avr 2013;49(4):780-92.
  2. Haastert-Talini et al. Chitosan tubes of varying degrees of acetylation for bridging peripheral nerve defects. Biomaterials 2013; 34: 9886-9904.
  3. The biocompatibility of Reaxon® Nerve Guide has been proven in accordance with the ISO 10993 standards.
  4. Marcol et al. Reduction of post-traumatic neuroma and epineural scar formation in rat sciatic nerve by application of microcrystallic chitosan. Microsurgery 2011; 31: 642-649.
  5. Rabea et al. Chitosan as antimicrobial agent: application and mode of action. Biomacromolecules 2003; 4: 1457-1465.
  6. Oliveira et al. Chitosan drives anti-inflammatory macrophage polarisation and pro-inflammatory denditric cell stimulation. Eur Cell Mater 2012; 24: 136-52
  7. Yuan et al. The interaction of Schwann cells with chitosan membranes and fibers in vitro. Biomaterials 2004; 25: 4273-4278
  8. Freier et al. Chitin-based tubes for tissue engineering in the nervous system. Biomaterials 2005; 26: 6424-6432.